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cules such as brinogen, IgM, and lipoproteins are mostly excluded from the CSF There are other notable differences between the protein fractions of CSF and plasma The CSF always contains a prealbumin fraction and the plasma does not Although derived from plasma, this fraction, for an unknown reason, concentrates in the CSF, and the level is greater in ventricular than in lumbar CSF (perhaps because of its concentration by choroidal cells) Also, the CSF beta2 or tau fraction (transferrin) is proportionally larger than that in the plasma and again higher in the ventricular than in the spinal uid The gamma globulin fraction in CSF is about 70 percent of that in serum At present only a few of these proteins are known to be associated with speci c diseases of the nervous system The most important is IgG, which may exceed 12 percent of the total CSF protein in diseases such as multiple sclerosis, neurosyphilis, subacute sclerosing panencephalitis, and other chronic viral meningoencephalitides The serum IgG is not correspondingly increased, which means that this immune globulin originates in (or is preferentially transported into) the nervous system However, an elevation of serum gamma globulin as occurs in cirrhosis, sarcoidosis, myxedema, and multiple myeloma will be accompanied by a rise in the CSF globulin Therefore, in patients with an elevated CSF gamma globulin, it is necessary to determine the electrophoretic pattern of the serum proteins as well Certain qualitative changes in the CSF immunoglobulin pattern, particularly the demonstration of several discrete (oligoclonal) bands and the ratio of IgG to total protein, are of special diagnostic importance in multiple sclerosis, as discussed in Chap 36 The albumin fraction of the CSF increases in a wide variety of central nervous system (CNS) and craniospinal nerve root diseases that increase the permeability of the blood-CSF barrier, but no speci c clinical correlations can be drawn Certain enzymes that originate in the brain, especially the brain-derived fraction of creatine kinase (CK-BB) but also enolase and neopterin, are found in the CSF after stroke or trauma and have been used as markers of brain damage in experimental work.

Power Supplies Always unplug the power supply from the wall outlet when you are working inside the computer Even when turned off, the power supply can conduct electricity Some technicians prefer to leave the power supply plugged in while they work on the computer to allow static to bleed away from the computer into the wall outlet s ground wire However, there are safer methods for removing static (discussed later in this chapter), so there is no need to leave the power supply plugged in As discussed previously, the power supply itself is able to store electrical charges for long periods of time, even when it has been unplugged Never open the power supply s case, and never wear an ESD wrist strap when replacing or handling the power supply ESD straps are designed to bleed static charges away from the computer, through your body If worn near a power supply, the strap could conduct high-voltage electricity as well as static charges These high voltages are enough to harm you

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Oracle Secure Backup (OSB) is a centralized tape backup management software providing solutions to back up and restore file systems and Oracle databases OSB is tightly integrated with RMAN features such as unused block compression and UNDO optimizations, and with this integration, it is able to deliver extremely efficient backup and restore operations OSB interfaces with the tape library for storing backups to tape A tape library is a device that contains two or more tape drives for reading and writing backup data, along with a collection of tape cartridges It is designed for continuous, unattended operations using robotic hardware that has mechanisms to scan, mount, and dismount the tape cartridges The OSB software that manages the tape library resides on a media server The media server facilitates communication with the tape devices, and is used by RMAN to perform tape backups The media servers connect to the Database Machine using the InfiniBand, the 1 Gigabit, or the 10 Gigabit Ethernet interfaces Using the InfiniBand interface gives you the best performance for backups and restores; however, this option requires the media servers to support the InfiniBand connectivity through a suitable Host Channel Adapter (HCA) that is compatible with the Database Machine An OSB backup domain is a network of backup clients, media servers, and the tape libraries The backup domain contains an administrative server that serves the backup clients, and also stores the OSB backup catalog The OSB catalog is the black box of the backup domain and contains information about the backups An architecture diagram of Oracle Secure Backup for performing backups of the Database Machine is provided later in this chapter in Figure 6-3 OSB Best Practices Consider the following best practices when configuring Oracle Secure Backup with the Database Machine:

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