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observations on muscle and nerve biopsies J Neurol Sci 1989;91(1 2):53 70 Borg K, Tome FM, et al Intranuclear and cytoplasmic lamentous inclusions in distal myopathy (Welander) Acta Neuropathol (Berl) 1991;82(2):102 106 Edstrom, L Histochemical and histopathological changes in skeletal muscle in late-onset hereditary distal myopathy (Welander) J Neurol Sci 1975;26(2):147 157 Markesbery WR, Griggs RC, et al Distal myopathy: Electron microscopic and histochemical studies Neurology 1977;27(8):727 735 Partanen J, Laulumaa V, et al Late onset foot-drop muscular dystrophy with rimmed vacuoles J Neurol Sci 1994;125(2):158 167 Udd, B Limb-girdle type muscular dystrophy in a large family with distal myopathy: Homozygous manifestation of a dominant gene J Med Genet 1992;29(6):383 389 Udd B, Bushby K, et al 104th European Neuromuscular Centre (ENMC) International Workshop: Distal myopathies, 8 10th March 2002 in Naarden, the Netherlands Neuromuscul Disord 2002;12(9):897 904 Udd B, Griggs R Distal myopathies Curr Opin Neurol 2001;14(5):561 566 Udd B, Haravuori H, et al Tibial muscular dystrophy from clinical description to linkage on chromosome 2q31 Neuromuscul Disord 1998;8(5):327 332 Udd B, Kaarianen H, et al Muscular dystrophy with separate clinical phenotypes in a large family Muscle Nerve 1991;14(11):1050 1058 Udd B, Partanen J, et al Tibial muscular dystrophy Late adult-onset distal myopathy in 66 Finnish patients Arch Neurol 1993;50(6):604 608 Udd B, Rapola J, et al Nonvacuolar myopathy in a large family with both late adult onset distal myopathy and severe proximal muscular dystrophy J Neurol Sci 1992;113(2):214 221 Hackman P, Vihola A, et al Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin Am J Hum Genet 2002;71(3):492 500 Markesbery WR, Griggs RC, et al Late onset hereditary distal myopathy Neurology 1974;24(2):127 134 Mizusawa H, Kurisaki H, et al Rimmed vacuolar distal myopathy: A clinical, electrophysiological, histopathological and computed tomographic study of seven cases J Neurol 1987;234(3):129 136 Nonaka I, Sunohara N, et al Familial distal myopathy with rimmed vacuole and lamellar (myeloid) body formation J Neurol Sci 1981;51(1):141 155 Nonaka I, Sunohara N, et al Autosomal recessive distal muscular dystrophy: A comparative study with distal myopathy with rimmed vacuole formation Ann Neurol 1985;17(1):51 59 Sunohara N, Nonaka I, et al Distal myopathy with rimmed vacuole formation A follow-up study Brain 1989;112(Pt 1):65 83 Argov Z, Eisenberg I, et al Hereditary inclusion body myopathy: The Middle Eastern genetic cluster Neurology 2003;60(9):1519 1523 Argov Z, Yarom R Rimmed vacuole myopathy sparing.

bottom_btnonRollOver = function():Void { hammer_mc_rotation = rotateAmt; nail_mc_y += bashAmt; rotateAmt -= bashAmt / 7; }

.

*myFuncPtr( int );

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SPECIFIC DISORDERS novel dominant negative alpha B-crystallin mutations Ann Neurol 2003;54(6):804 810 Selcen D, Ohno K, et al Myo brillar myopathy: Clinical, morphological and genetic studies in 63 patients Brain 2004;127(Pt 2):439 451 Vicart P, Caron A, et al A missense mutation in the alphaBcrystallin chaperone gene causes a desmin-related myopathy Nat Genet 1998;20(1):92 95 Nakano S, Engel AG, et al Myo brillar myopathy III Abnormal expression of cyclin-dependent kinases and nuclear proteins J Neuropathol Exp Neurol 1997;56(8):850 856 Bertini E, Biancalana V, et al 118th ENMC International Workshop on Advances in Myotubular Myopathy, 26 28 September 2003, Naarden, the Netherlands (5th Workshop of the International Consortium on Myotubular Myopathy) Neuromuscul Disord 2004;14(6):387 396 Sabatelli M, Bertini E, et al Peripheral neuropathy with giant axons and cardiomyopathy associated with desmin type intermediate laments in skeletal muscle J Neurol Sci 1992;109(1):1 10 Munoz-Marmol AM, Strasser G, et al A dysfunctional desmin mutation in a patient with severe generalized myopathy Proc Natl Acad Sci USA 1998;95(19):11312 11317 Li M, Dalakas MC Abnormal desmin protein in myo brillar myopathies caused by desmin gene mutations Ann Neurol 2001;49(4):532 536 Griggs RC, Askanas V, et al Inclusion body myositis and myopathies Ann Neurol 1995;38(5):705 713 Sivakumar K, Dalakas MC Inclusion body myositis and myopathies Curr Opin Neurol 1997;10(5):413 420 Amato AA, Collins MP Neuropathies associated with malignancy Semin Neurol 1998;18(1):125 144 Tajsharghi H, Darin N, et al Mutations and sequence variation in the human myosin heavy chain IIa gene (MYH2) Eur J Hum Genet 2005;13(5):617 622 Cole AJ, Kuzniecky R, et al Familial myopathy with changes resembling inclusion body myositis and periventricular leucoencephalopathy A new syndrome Brain 1988;111(Pt 5):1025 1037 Watts GD, Thorne M, et al Clinical and genetic heterogeneity in chromosome 9p associated hereditary inclusion body myopathy: Exclusion of GNE and three other candidate genes Neuromuscul Disord 2003;13(7 8):559 567 Watts GD, Wymer J, et al Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein Nat Genet 2004;36(4):377 381 Martinsson T, Darin N, et al Dominant hereditary inclusion-body myopathy gene (IBM3) maps to chromosome region 17p131 Am J Hum Genet 1999;64(5):1420 1426 Martinsson T, Oldfors A, et al Autosomal dominant myopathy: Missense mutation (Glu-706 > Lys) in the myosin heavy chain IIa gene Proc Natl Acad Sci USA 2000;97(26):14614 14619.

289 290 291

You may be wondering where the number 7 came from This number actually came from a trial and error process when I initially created the game At the end of this exercise, you can change this number to modify the change in rotation amount for the hammer if you d like to see what a different value would look like

myFuncPtr = main; *myFuncPtr();

292 293

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s[ 20 ];

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